If You’re Looking For The Best Vitamins, Herbs, and Supplements For Neuropathy, Then Keep Reading!

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Neuropathy refers to the condition where the peripheral nerves are not working properly. It is estimated that approximately 21 million people in the USA have some form of neuropathy.

Among this population, diabetes is termed to be the leading cause of peripheral neuropathy. Pain related to neuropathy is characterized by numbness and pain in lower legs, imbalance, and discomfort. It can be quite devastating, and may affect up to 8% or more in a population.

Our detailed guide below will explain the difference between conventional treatments versus natural supplements, and what to look for in choosing a product that works.

What Are the Most Common Conventional Nerve Pain Treatments?

1. Antidepressants

Antidepressants are not only used for relieving depression but also chronic pain. These drugs are also associated with improved quality of sleep, a factor that play a huge role in reducing pain. Some of the antidepressants that are used in the treatment of neuropathy include:

  • Norepinephrine Reuptake Inhibitors (For instance, Wellbutrin®)
  • Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs) (such as Cymbalta>®)
  • Selective Serotonin Reuptake Inhibitors (SSRIs)
  • Serotonin Receptor Modulators (SRM)

2. Anticonvulsants

There is no evidence of the use of ant-seizure drugs, with the exception of carbamazepine which is used for trigeminal neuralgia, as the first-line treatment. Some drugs such as gabapentin have shown to produce effects in post-herpetic neuralgia and diabetic neuropathic pain. In an effort to minimize side effects and enhance effectiveness, anticonvulsants should be avoided if they do not have any clinical effect in neuropathy.

3. Opioids

Opioids alleviates pain by agonizing the mu opioid receptors in the peripheral nervous systems. Although their action produces analgesic effect to a greater extent, they can also lead to life-threatening adverse events. These include reduced chemoreceptor response to carbon (IV) oxide, which may lead to accumulation of the gas - increasing the possibility of contracting lethal respiratory depression.

Additionally, they may cause euphoria which may result in addiction, misuse, and abuse. Opioids that may be used in treating neuropathy include methadone, morphine, oxycodone, oxymorphone, tapentadol, and tramadol among others.

4. OTC Pain Killers

Among the pain killers, over-the-counter ones are the most frequently purchased drugs. They are indicated on instances of mild to moderate pain that comes as a result of peripheral neuropathy.


Acetaminophen acts as both an antipyretic (reduces fever) as well as treat pain ranging from mild to moderate. It works by increasing the amount of pain that you can tolerate before you can experience the pain.

Nonsteroidal anti-inflammatory drugs (NSAIDs)

NSAIDs reduce stiffness, pain, swelling and some alleviate fever. There are several types of nonsteroidal anti-inflammatory drugs including Ibuprofen, ketoprofen, naproxen, aspirin among others.

These drugs act by decreasing the production of prostaglandin, a substance involved in sending pain messages to the brain.

The Downsides of Conventional Neuropathy Treatments

1. Side Effects

  • Anti-seizure drugs such as sodium valproate, phenytoin, and carbamazepine may cause dysfunction of the liver and blood dyscrasias.
  • Opioids such as tramadol or oxycodone can lead to addiction and the patient being dependent on the drug. Therefore, these drugs are indicated only when others have failed.
  • Anti-seizure medications such as gabapentin and pregabalin have side effects like dizziness and drowsiness.
  • Antidepressants may lead to nausea, dry mouth, dizziness, drowsiness, constipation, and decreased appetite.

2. Expensive

  • Prescriptions that are used to relieve pain in peripheral neuropathy include anticonvulsants and antidepressants. The cost of anti-seizure drugs such as >pregabilin and gabapentin may range up to $500 or more for a month’s supply.
  • On the other hand, commonly used antidepressants may go for $400 a month. These values go even higher when the patient requires a specific drug or generic version.
  • Another option for pain management in peripheral neuropathy is Transcutaneous Electrical Nerve Stimulation (TENS), a medical device that is non-invasive and uses electrodes. This intervention for pain control can cost $700 or more. Additionally, some insurance companies tend not to cover TENS units.

3. They Don't Address the Root Causes

Conventional medicines tend to look at each disease as an isolated entity with one treatment and one cause. This type of thinking often overlooks the root cause of everything.

They then issue each problem a name, and each of which is given a medication or two, the patient then ends up with almost ten drugs while no one addresses the underlying physiologic imbalance.

This results in the patient getting even sicker, and collects more diagnoses which mean that they will collect more medication meaning more side effects.

What Are The Best Supplements & Vitamins For Neuropathy That Support Overall Nerve Health?

Alpha-lipoic acid

This is an antioxidant that is found in many of the foods we eat and it may be synthesized by our bodies. High amounts of alpha-lipoic acid have been used in some parts of Europe to treat some types of neuropathy. But studies strongly suggest its importance in diabetic peripheral neuropathy.

Scientific evidence is available to support the significance of alpha-lipoic acid in fighting type 2 diabetes. Studies have linked its use to improving insulin resistance. Studies have also shown that alpha-lipoic acid is effective when treating nerve damage that is as a result of diabetes or cancer treatment. They seem to alleviate symptoms such as prickling, pain, and tingling in the legs and feet.

Which foods have alpha-lipoic acid?

Numerous foods have the ingredient alpha-lipoic acid, but it is usually in low amounts. They include broccoli, yeast, spinach, rice bran, tomatoes, yams, carrots, Brussels sprouts, beets, and potatoes. Red meat – and mainly organ meat – also contain alpha-lipoic acid.


This supplement is part of the B-12 vitamin complex. This vitamin is widely available and no one should take advantage of this because it is not prescribed. This vitamin is free and has no side effects.

So, what is this nutrient and how does it come in play in a person suffering from neuropathy? Vitamin B-12 is a term that is assigned to certain biological compounds that are known as cobalamins.

Cobalamins have structures that are related to hemoglobin. Vitamin B-12 deficiency can cause anemia. Cyanocobalamin is the most common form of vitamin B-12, and it is usually the one indicated on the bottle as the ingredient. Recently, scientist have linked some peripheral neurological conditions to deficiency of a specific coblamin which is the methylcobalamin form.

Methylcobalamin is crucial to protect one against aging and peripheral neurological diseases. The liver derives methylcobalamin from cyanocobalamin, but quite a huge amount is needed to correct peripheral neurological defects.

In fact, there are published studies present at the moment attributing high doses of methylcobalamin to the regeneration of neurons and myelin sheaths that protect axons. Wow! This is good news to those with peripheral neuropathy! There seem to be some light at the end of the tunnel, better still the help comes from a natural source. It can’t get any better than that.


Lack of vitamin B1 (thiamine) is common among people with peripheral neuropathy. In fact, it is known to be the cause of peripheral neuropathy. Research done in 2007 tried to consider patients with type I and II diabetes with 75% decrease in the levels of thiamine in blood plasma and compared to patients who did not have diabetes.

It was observed that there was increased clearance of thiamine in urine among patients who had diabetes. Additionally, patients who had heart problems and were put on diuretics also experienced high clearance of thiamine in urine.

Treatment of peripheral neuropathy has been a real issue among health care workers. There exist an extensive list of non-specific medications that have adverse side effects that are being used for treating neuropathy. Topical, injections, and therapy treatment means are insufficient.

Supplementation of thiamine, over the years, for patients with neuropathy has shown a little success. However, a lipid soluble analog of thiamine known as benfotiamine has shown huge success in combating peripheral neuropathy.

Natural Herbs For Neuropathy

Skullcap Extract

The herb Skullcap extract has been known to have health benefits for conditions such as anxiety or insomnia, and can be used treat neurological disorders. Skullcap extract demonstrated effectiveness in treating seizures and muscle spasms. Due to its excellent anti-inflammatory properties, it can also be used to reduce pain for patients with diabetes and neuropathy.

Feverfew Extract

Feverfew Extract is an herb obtained from daisy plant. This extract has found uses for numerous conditions such as chronic pain, migraines, infections on the skin, inflammation, asthma and much more. It has also been used to relieve neuropathic pain.

Oatstraw Extract

This herb obtained by cultivating the leaves and the stems of the green which is the unripe section of the oat plant.  These extracts have high amounts vitamins E, D, B1, and B2 as well as minerals such as iron and calcium.

In addition to its role improving the brain power, studies have shown that Oastraw Extracts can be important to patients with anxiety.

Passion Flower Extract

Passion Flower Extract is an herb mainly used for the purpose of relieving pain. Doctors have embraced the use of passion flower extract when combating peripheral neuropathy. Initially, it was used as a sedative but later found to have pain relieving properties since it is rich in alkaloids such as harmine and harmalol. It is also rich in flavonoids.

What To Look For In The Best Neuropathy Supplement

Nerve pain seem to be resistant to OTC painkillers, with the targeted prescriptions even failing to offer significant health benefits.

The solution to this problem revolves on managing the pain by supporting the nervous system with the right vitamins and nutrients.

Therefore, we need to choose natural supplements that will reduce transmission of false signals to the peripheral nerves and deliver the optimal dosages of supplements and vitamins to promote nerve growth, regeneration, and maintenance.

We thoroughly researched what the most effective natural supplements and vitamins are for peripheral neuropathy. In our research, we discovered several generic solutions and some more specialized. After compiling a list of what is medically proven and effective, we narrowed the list based on 3 important criteria shared by all. These criteria are:

1. High Bioavailability

Bioavailability refers to the proportion of a substance or a drug to enter the systemic circulation when introduced into the body and, therefore, can carry out its intended action.

High bioavailability of a neuropathy supplement will ensure that the maximum amount of the supplement required to exert the intended function reach the target organ.

2. Proper Dosage

Some supplements need to be administered in just the right dosage. Any excess will mean that it will be ineffective or cause adverse events. Therefore, a good neuropathy supplement needs to be administered in a proper dosage.

3. Pure Ingredients

Nothing is as important in a neuropathy supplement as the ingredients. Presence of impurities in a supplement will impair its function. Therefore, a good supplement needs to have pure ingredients.

How We Selected The Best Companies

Excellent Customer Support

There is nothing that enhances customer trust on a product than an excellent support service. Being there for a customer whenever they need clarifications on any issues that may concern the product.

We look for companies that offer excellent services to their customer any time they may have questions on the product. We believe that with happy customers, we have a happy team.

Strong Money Guarantee

We select companies that offer customers the best products. Those that issue customers the services that will guarantee value for their money. We also choose companies that are ready to refund customers within reasonable time of purchase if the product doesn’t prove effective as anticipated.

Positive Online Reviews and Testimonials

We love working with companies that our customers will like. What is the best way to get to know if a company you choose will satisfy your clients than going through their reviews and checking up reviews from previous customers?

Our success is measured against customer satisfaction that is why we exercise extreme caution when selecting companies we are going to work with.

8 Best Neuropathy Supplements
[Updated: ​May 25, 2020]

1. Nerve Renew - Best All Around Supplement For Nerve Pain Relief

A bottle of the best neuropathy supplement for nerve regeneration

In our opinion, Nerve Renew is the top nerve support formula available. It has several natural ingredients, and all of them are clinically studied in regards to relieving neuropathic pain. In its most effective form, it consists of pure ingredients, and the entire action is positive and efficient.


  • Prevents nerve damage as it promotes nerve regeneration at the cell level.
  • Minimizes the numbness in hands, legs, and feet
  • It increases vascularity to the brain thereby increasing blood supply. It later increases blood supply to the areas affected.
  • It decreases the burning-like sensation in feet and hands
  • Increases quality of sleep by eliminating insomnia and irritability. This is made possible due to its antidepressant and anti-anxiety properties.


No negative complaints have been raised. However, Nerve Review is not meant to be used by pregnant and breastfeeding mothers.

2. Nervexol

Nervexol was a solution born out of necessity by a husband and wife. Kierstyn developed painful, debilitating neuropathy and couldn't do the things she loved.

So Sam, her husband, started testing different combinations of vitamins and herbs until Kierstyn found relief. They developed this solution into a formula and began offering it to the public and the response was so positive, they decided to turn it into an official company.


  • Natural formula, free of side effects or interactions.
  • Proven ingredients backed by multiple scientific studies.
  • Helps ease pain and burning and promotes relaxation and quality sleep.
  • May help nerve regeneration if consistently taken over time.
  • 180 day money back guarantee


  • No cons about the product itself
  • Their guarantee is not as long as Nerve Renew, but 180 days is plenty to see relief and also more than all other products listed below.

3. Neuropaquell

A single bottle of Neuropaquell nerve pain supplement

Neuropaquell is a quite advanced as a nerve pain supplement and may also help relieve of neuropathic pain, which is why we rated it as our second best option. It can compete with medical prescriptions made by the doctor to combat pain. It boasts of better B vitamins, and ensures better absorption.


  • Has a clinical strength since it can reduce fever without prescribing
  • Plays a great role in alleviating neuropathic pain
  • Has better vitamin B than other typical supplements
  • It has a money back guarantee if it does prove effectiveness


  • Neuropaquell suggests to consult a doctor before taking the supplement.

4. Nerve Shield

Nerve Shield box by REDD Remedies

Nerve Shield is a simple supplement formulation that is gluten-free and all-natural with most of the common ingredients that support healthy nerve functioning.


  • Promote a healthy myelin sheath or nerve structure
  • An antioxidant, it prevent formation of free radicals.
  • Support a healthful inflammatory response
  • Promote better circulation


No side effect reported.

5. Nervestra

Single bottle of Nervestra liquid supplement

Nervestra is an all-natural and quick acting liquid supplement that aims at enhancing the health of the nerves and proper nerve function.


  • Improved health of the nerves when using Nervestra
  • Benefits of using the supplement are witnessed within a short period
  • Affordable and possibility of money guarantee if ineffective
  • Relief pain in the body for those depending on it.


  • Some people do not like the taste of the liquid

6. Nerve Support Formula

A bottle of Nerve Support Formula by Real Health Products company

Nerve Support Formula is basic formula that consists mainly of methylcobalamin and benfotiamine – the two vitamins that are essential for healthy nerves.


  • Promotes nerve regeneration
  • Prevent nerve damage
  • Increase vascular supply to the body


  • Has no side effects

7. Nerve Pain Away

Nerve Pain Away single spray bottle

Nerve Pain Away is a topical supplement aims at alleviating the tingling, pain, and burning of the feet and hands by those suffering from diabetic peripheral neuropathy. It is also important when it comes to sciatica and conditions related to nerve pain. It is used by spraying Nerve Pain Away on the affected area and then massaging deep into the skin at that area.


  • Swift relief for pain related to diabetes
  • It is drug free and can be safely used with regular prescriptions
  • Alleviates the burning, tingling, and numbness in feet and hands


  • Ingredients Accontium nepellus and Secale cornutum cause unconsciousness, gangrene, vomiting, confusion, sweating, spasms, vision problems, breathing problems, nausea, weakness or inability to move, heart problems, and convulsions.
  • The ingredient Rhus tosicodendron also known as Poison Ivy can cause swelling, severe skin destruction, redness, blisters, loss of sight, or swelling of the cornea.

8. Neuracel

Neuracel bottle front

Neuracel is an all-natural complete supplement consisting of numerous organic ingredients. These ingredients aim to alleviate neuropathic pain. It is non-addictive and anyone who would use it without fear of addiction.


  • Encourages muscle relaxation
  • Reduces stiffness and improves flexibility
  • Reduces muscle pain and aches
  • Reduces nerve discomfort


  • Headaches
  • Digestive problems
  • Questionable marketing

Which Neuropathy Supplement Is The Best?

After doing a lot of research, we can conclude that the best all-round supplement for reducing neuropathic pain is Nerve Renew.

Nerve Renew Advanced Nerve Support is the best supplement for neuropathy and nerve pain in 2020.

Here is why we recommend it:

  • The product contains all the ingredients that we discussed above in the correct dosages for maximum effect.
  • The majority of reviews from customers are positive. They had a noticeable reduction in pain and symptoms.
  • Additionally, the company has an excellent customer services with prompt reply to messages.
  • They have a 365 day no-question asked money guarantee, so you can try the product as long as you need to see results.
  • They are Doctor Recommended and have a medical advisory board.

Where To Buy

After researching several purchasing options online, we've found the safest and most budget-friendly way to purchase on the official website at the link below. Use the link below for best savings and to avoid knock-offs and copycats.