Nerve Pain Relief Cream: Top 5 Neuropathy Treatments 2023

Nerve pain can be debilitating. People who suffer from it can have tremendous difficulty going about their daily lives unless they can control it adequately. Dealing with nerve pain on top of everything else life throws out can make someone's day feel unbearable.

Some of the most acute nerve pain comes from a condition known as peripheral neuropathy. While patients can experience this pain anywhere, it often affects the body's extremities, such as the feet and hands. However, the good news is that there are various treatments currently available to provide relief from this issue.

Treatments for Nerve Pain

Some conventional treatments for nerve pain include:

  • Pain-relieving medicine
  • Antidepressants
  • Anti-seizure medication
  • Topical treatments

Some studies have even shown antihistamines to be promising in reducing nerve pain from peripheral neuropathy. This discovery means that medication like Benadryl might also be helpful in the fight against neuropathy pain.

While you can purchase some pain treating drugs over the counter, other strong pain relievers require a prescription. Usually, doctors prescribe these intense medications as a last resort because they can be habit-forming. Long-term usage of pain medication, for example, can lead to dangerous and unhealthy habits.

Topical treatments are substances applied directly to the skin to provide relief. They can come in the form of creams, oils, or ointments. Cream tends to be the most popular form. Sometimes patients use a combination of oral pn medication and topical treatments to get complete relief from their pain.

Is There a Cream for Neuropathy?

Yes! Many creams are available to treat pain from neuropathy. However, the variety can make it challenging to choose the best one.

Many people prefer using topical treatments for neuropathy pain because they have fewer side effects and less chance of developing a dependency or addiction. If you are looking for the perfect cream to fight your nerve pain, you have come to the right place.

Keep reading to learn how creams prevent nerve pain and discover some promising products that may help you find the relief you seek.

How Do Neuropathy Pain Relief Creams Work?

Creams usually relieve the nerve pain caused by neuropathy by using powerful active ingredients that absorb through the skin to treat the affected area directly. Some of the most common elements are Vitamin E, MSM, and capsaicin.

When people are deficient in Vitamin E, they may be more susceptible to developing neuropathy and nerve pain. Taking a Vitamin E supplement has proven to promote nerve regeneration. It provides powerful relief from nerve pain.

Methyl-Sulfonyl-Methane (MSM) is a potent anti-inflammatory substance. It can help your body rid itself of toxins and provide much-needed pain relief.

Finally, capsaicin is a substance found in hot peppers. It can work wonders to stop neuropathy in a cream you apply to your skin.

Most creams include one or more of the above used with other ingredients. They provide users with quick relief from the symptoms of peripheral neuropathy. They also enable those who suffer from neuropathy to use topical treatments without the risk of addiction.

Top 5 Topical Oils and Creams for Neuropathy

Let's review some of the top-ranked oils and creams that provide pain relief for peripheral neuropathy. These five products have successfully alleviated symptoms in the majority of patients that use them.

If you earnestly seek pain relief from your neuropathy pain, keep reading this review to discover a cream that may provide you with the relief you desire. This list will give you the perfect place to start your search for pain relief from neuropathy. You can order each option we've reviewed online.


The main active ingredients in NERVEX are:

  • Vitamin E
  • Vitamin B12
  • Capsaicin

Capsaicin is a powerful ingredient used in this substance to treat neuropathy.

The cream is gentle on the skin and does not cause burning because it consists of all-natural ingredients. This cream also features moisturizers and antioxidants that help it absorb thoroughly into the skin to deliver pain relief even more quickly. Another perk of this cream is that it is odorless, so no one will notice that you are using it. This pain reliever is also affordable and the cheapest option on this list. People who use this product say that it helped reduce their numbness, muscle spasms, and pain.

The biggest con of this product is that it does not appear to work for everyone. One user stated that they used it on their foot and that the application site began to burn more than it had initially.


  • Reduces numbness, spasms, pain
  • Gentle on skin
  • All-natural ingredients
  • Moisturizers and antioxidants included
  • Odorless
  • Affordable


  • Not for everyone - some users reported no positive effects from the cream

#2 Nerve Reverse

NerveReverse nutrition for nerves - Maximum strength Pain-Relief cream

This cream works to get right to the source of your neuropathy pain using:

  • MSM, L-Arginine
  • L-Carnitine
  • alpha-lipoic acid
  • Menthol
  • Vitamin E

The formula soothes the burning sensation of peripheral neuropathy. It works diligently to provide relief by reducing inflammation and improving blood flow. The product comes with a money-back guarantee that will allow you to use it and determine its effectiveness. The company also offers free shipping, which can help defray the overall cost compared to other options.

Nerve Reverse is one of the more expensive options on this list, which is critical to keep in mind if you are on a tight budget.


  • Soothes burning and inflammation
  • Improves blood circulation
  • Money=back guarantee
  • Free shipping


  • Expensive

Editor Recommendations:

#3 Nuturna Neuropathy Cream

Nuturna Neuropathy cream

This fast-acting cream soothes peripheral neuropathy with the help of:

  • Vitamin E
  • Vitamin B6
  • Arnica
  • Menthol
  • MSM
  • Tea tree oil
  • Aloe vera

The cream works to quickly provide users with soothing relief by reducing swelling and increasing blood circulation. Nuturna carefully researches each ingredient to ensure its customers can trust the products. The company has been providing pain relief for over ten years, so the odds are that they are doing something right in the fight against painful neuropathy to operate for all this time successfully. It is also apparent that many a doctor will recommend this cream to help their patients find pain relief.

While this cream has an impressive ingredient list, the manufacturers suggest consuming supplements in addition to the cream, which is a bit of a red flag. Some users think that if the cream were effective in its own right, then they should not have to take supplements to get the full effect. However, if you already take supplements, then this may not be a big deal for you.


  • Reduces inflammation
  • Increases blood flow
  • Trusted manufacturer


  • Requires supplemental intake with creams

#4 Myomed P.R.O.

Myomed PRO

This treatment is a blend of powerful essential oils that target the affected area and quickly bring pain relief.

You will not have to worry about suffering side effects from harmful synthetic chemicals when you have a product with exclusively all-natural ingredients. Pharmaceutical substances can wreak havoc on your skin and leave the affected area in more pain than there was initially.

You can avoid all these skin problems with this homeopathic cream. Myomed P.R.O. never tests its products on animals, meaning you can enjoy pain relief from this cream without any guilt. The product is also made in the United States if you want to support a domestic company while relieving your pain. This patented product has all rights reserved.


  • Essential oils
  • All-natural ingredients
  • Cruelty-free
  • USA-made


  • Pricey

#5 Nerve Renew Cream

Nerve Renew Fast Acting Cream

This potent cream absorbs through your skin to provide much-needed pain relief from neuropathy symptoms.

Many customer reviews have spoken its praises because of its ability to alleviate tingling and numbness. It is safe to use for people who suffer from multiple related conditions, including arthritis, diabetes, and other chronic health issues.

The product also comes with a one-year warranty. Having a full year provides most users with plenty of time to accurately determine the product's effectiveness. If you are not getting the results you desire, you can recoup your investment and find a cream that will provide the pain relief you need.

The price is a tad high, but if you sign up for a subscription, you can save 20%. Check out our Nerve Renew review for more information about their product to see if their solutions will work with your condition.


  • Alleviates tingling and numbness
  • Safe for users with other chronic illnesses
  • One-year warranty
  • 20% off with subscription


  • Pricey


Upon review, you will likely experience positive results from any of these creams. They all have shown promise in relieving the symptoms of overactive nerves and providing relief.

You should always consult your medical doctor before you begin to use a new cream or product. You want to get all the information you need and reduce your likelihood of having an adverse reaction. Your doctor will help you find which treatments neuropathy will be better for you to try and allow you the most pain relief.

You deserve to feel relief from your pain. Hopefully, a neuropathy cream will help you get well in time to start living your life pain-free as quickly as possible.